Spectrum of Malignant and Non-Malignant Hematological Disorders in a Tertiary Care Centre

  • Muhammad Ihtesham Khan Department of Pathology, Khyber medical college, Peshawar
  • Nuzhat Yasmeen Oncology department, Children hospital, Pakistan Institute of Medical Sciences, Islamabad
  • Syeda Hina Fatima Department of Pathology, Khyber medical college, Peshawar
Keywords: Acute leukemia, Anemia, Bone marrow biopsy, Megaloblastic anemia, Multiple myeloma


Objective: To analyze the spectrum of malignant and non-malignant hematological disorders in our setup.
Patients and Methods: This cross-sectional study was done in the Department of Pathology, Khyber Teaching Hospital, Peshawar, from 1st January -2016 to 30th December-2016. A total 352 patients underwent bone marrow biopsy during study period. About 15 patients had inadequate aspirate samples that were unfit for opinion. So these were excluded from the study. The remaining of 337 patients were included in the study. All patients of both sexes and all ages were included in the study. Bone marrow aspiration and biopsy was done, the slides were stained, examined and diagnosis was recorded. Data was analyzed by SPSS version 16 and results were drawn accordingly.
Results: Among total 337 patients, there were 185 (55%) male and 152 (45%) females. Male to female ratio was 1.2:1. The median age of participants was 26 years and range was 9 months -72 years, (mean age was 36±17.8 years). Regarding pattern of hematological illnesses, commonest non-malignant disorder was Megaloblastic anemia. Among malignant hematological illnesses, frequent disorder was Acute Lymphoblastic Leukemia.
Conclusion: Megaloblastic anemia, Hemolytic anemia, and Aplastic anemia are common non-malignant hematological disorders in our setup. Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia and Multiple Myeloma are common malignant hematological disorders in our set up. 

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