Primary Adenosquamous Carcinoma of Prostate: A Rare Aggressive Tumor
Adenosquamous carcinoma is an aggressive tumor of prostate with only 30 cases reported so far in literature. We present a case of this rare entity that was seen in our department. A 70 years old male presented with urinary outflow obstruction and slightly raised PSA levels [5mg/ml (normal; 0-4 mg/ml)]. Transuretheral resection of prostate was done and specimen was sent to our department. Histologically, it composed of both malignant squamous and glandular components. Squamous component showed large tumor cells with abundant cytoplasm and nuclei with prominent nucleoli. Glandular component showed tumor cells arranged in acinar pattern, predominantly in cribriform architecture. As the current guidlines, Gleason grading is not required for adenosquamous carcinoma of prostate. The case was reported as the adenosquamous carcinoma of prostate. This rare tumor has an extremely poor prognosis with most of the patients dying within 1 year of diagnosis.
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