Trends of Antimicrobial Sensitivity Among Common Isolates in a Tertiary Care Hospital, Rawalpindi

  • Uzma Mussarat Department of Pathology, Islamic International Dental College, Riphah International University, Islamabad https://orcid.org/0009-0006-5755-3150
  • Shazia Taj National University of Science and Technology, Islamabad
  • Shahina Yasmin Department of Pathology, Islamic International Medical College, Riphah International University, Islamabad
  • Aleena Butt Islamic International Dental College, Riphah International University, Islamabad
  • Nehaj Tariq Department of Pathology, WATIM Medical & Dental College, Rawalpindi
  • Tahira Inam Department of Pharmacology, Islamic International Dental College, Riphah International University, Islamabad

Abstract

Objective: To evaluate the resistance patterns of frequently found pathogens to different antimicrobial agents, aiding physicians in choosing appropriate treatment strategies for patients within our locality.

Materials and Method: This retrospective observational study took place at Pakistan Railway hospital (PRH) Rawalpindi; from January 2021 to December 2021. Data was obtained from the institute's database, the Hospital Information Management System (HIMS). Pathogens were identified in the laboratory through Gram staining and biochemical tests, and their antibiotic sensitivity profiles using disk diffusion method assessed following protocols established by the Clinical & Laboratory Standards Institute. Statistical analysis was conducted using SPSS version 24, and data entry was carried out accordingly.

Results: Overall, 1128 positive cultures were reported in study period including urine, pus, HVS, sputum cultures, stool, blood, catheter tip, and others (tissue fluid, wound, and cannula tip etc.). They comprised 32.8 %, 30.9 %, 16.6%, 5.05 %, 3.81%, 3.72 %, 1.15%, 0.70 % and 0.08% of the other specimens respectively. Among the isolates, Escherichia coli revealed 31.4% resistance against one of the third-generation cephalosporin and 8% to imipenem while Klebsiella pneumoniae exhibited 58.7% resistance. Moreover 82% Staphylococcus aureus were resistant to oxacillin, and 6% to vancomycin.

Conclusion: Moderate to reduced susceptibility to frequently utilized antimicrobials has been noted across diverse gram-positive and gram-negative species, apart from Penicillin. To address the escalating resistance to carbapenems and cephalosporins, it is essential to establish and enforce rigorous infection control measures.

Author Biographies

Uzma Mussarat, Department of Pathology, Islamic International Dental College, Riphah International University, Islamabad

Dr Uzma Mussarat, graduated from Fatima Jinnah Medical College, Lahore in 1999 in M.B.B.S. I am presently serving at Islamic International Dental College, a constitute college of Riphah International University, Islamabad, as Head of Dept of Pathology. I did MS Biosciences in Microbiology from COMSATS University Islamabad and did my M.Phil in Pathology (Microbiology) from Islamic International Medical College.

Shazia Taj, National University of Science and Technology, Islamabad

Dr Shazia Taj presently serving as Asst Prof at Dept of Pathology in Medical School of NUST.

Shahina Yasmin, Department of Pathology, Islamic International Medical College, Riphah International University, Islamabad

Dr Shahina Yasmin is presently serving as Prof in Dept of Pathology, at Islamic International Medical College.

Aleena Butt, Islamic International Dental College, Riphah International University, Islamabad

Dr Aleena Butt was PG Trainee at Islamic International Dental College, Islamabad.

Nehaj Tariq, Department of Pathology, WATIM Medical & Dental College, Rawalpindi

Dr Nahaj Tariq presently serving at WATIM Medical & Dental College Rawalpindi as Senior Lecturer in Dept of Pathology.

Tahira Inam, Department of Pharmacology, Islamic International Dental College, Riphah International University, Islamabad

Dr Tahira Inam is presently serving as Asst Prof at Islamic International Dental College in Dept of Pharmacology.

Published
2024-09-16
Section
Original Articles