Correlation between Glycated Hemoglobin and Dyslipidemia in Type-2 Diabetes Mellitus

  • Maqsood Ahmad Medical Lab Scientist, Dept of Chemical pathology, University of Health Sciences, Lahore
  • Iqra Ijaz Dept of Morbid Anatomy and Histopathology, University of Health Sciences, Lahore
  • Nadia Rasheed Senior Research Officer, Dept of Chemical Pathology, University of Health Sciences, Lahore
Keywords: Cardiovascular diseases, Diabetes mellitus type 2, Dyslipidemia, Glycated haemoglobin

Abstract

Objective: To evaluate correlation between glycated haemoglobin and dyslipidaemias in patients with type-2 Diabetes Mellitus (DM).
Patients and Methods: Participants were selected from out-patient department of Sheikh Zayed Hospital, Lahore and Laboratory analysis was performed at department of chemical pathology, University of Health Sciences, Lahore. Total 60 patients of type-2 DM and 40 age and gender matched controls were included in study. Glycated haemoglobin (HbA1c), fasting blood glucose (FBG) and lipid profile was performed after overnight fasting. Control group was labelled as Group-A and patient group was labelled as Group-B. Mean of all parameters from both groups was compared and checked for significance by independent sample t-test and Pearson correlation.
Results: There was no significant difference in mean values of all biochemical parameters between both genders, except total cholesterol, which was found higher in females (pvalue 0.047). Only 3.3% (n = 02) patients had normal lipid profile, 76.6% (n = 46) had one-abnormal parameter of lipid profile, 28.3% (n = 17) patients had two-abnormal parameter of lipid profile and 58.3% (n = 35) had mixed type of dyslipidemia. HbA1c was positively correlated with all parameters of lipid profile except HDL-C, which was negatively correlated.
Conclusion: There is positive correlation between level of glycemic control (HbA1c) and severity of dyslipidemia in patients of type 2 DM.

Published
2017-01-08
Section
Original Articles