Evaluation of Frequency of Beta Thalassemia Trait Among Pregnant Females
Abstract
ABSTRACT:
Objective: To determine the frequency of Beta thalassemia trait in pregnant females
Results: A total of 200 pregnant females, who presented for the first time in antenatal clinics of Shifa International Hospital were included in the study. 11% women were diagnosed as beta thalassemia trait, 29% had normal hemoglobin studies with concomitant iron deficiency anemia. 1.5% were diagnosed as cases of Hemoglobin-D trait, 1% as Hemoglobin-S trait and 0.5% as Hemoglobin-E trait. Among females, who were diagnosed with beta thalassemia trait,17.6% had cousin marriage and 12.5% had positive family history of thalassemia.
Conclusion: This study establishes, that the frequency of β-thalassemia trait amongst pregnant females was alarming (11%), highlighting the importance of routine screening in antenatal clinics.
A robust protocol for early identification of thalassemia carriers and to implement appropriate genetic counselling and management strategies is the need of the hour in a country like Pakistan showing highest birth rate.
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