Assessing the Vitamin-D (Calciferol) Supplementation Impact on Glycemic Levels among Patients with Type-2 Diabetes (DM-2); A Quasi-Experimental Trial
Abstract
Background: Calciferol has vital role in maintenance of glucose levels by its action on VDR receptors which are located on beta cells of the pancreas after that leading to the surge in insulin secretion as well as improvement of insulin sensitivity offered by an increased expression of insulin receptors
Objective: To determine the effect of Vitamin-D (calciferol) on the control of blood glucose (measured in terms of mean reduction of ≥1 in HbA1c) in calciferol deficient and insufficient diabetics, who have poorly controlled DM-2
Methodology: A Quasi-Experimental trial at the Department of Medicine, Fauji Foundation Hospital, Rawalpindi for 06 months was conducted after, meeting inclusion and exclusion criteria. 115 patients were enrolled and effect of calciferol on levels of blood glucose was assessed by measuring HbA1c levels, and pre-& post calciferol supplementation.
Results: Results showed mean of ages was 57.80 ± 7.64 years, 39(33.91%) patients were male and 76(66.09%) patients were females. On pre-intervention, the mean HbA1C of the patients who participated was 7.99 ± 0.48 while on post-intervention the mean HbA1C of the patients was 7.97 ± 0.48 (p-value=0.7523).
Conclusion: Effect of calciferol on glycemic control (measured in terms of mean reduction of ≥1 in HbA1c) in calciferol-deficient and insufficient diabetics was insignificant. Therefore, vitamin D supplementation appears to have no effect on blood glucose control in diabetes individuals who have low levels of calciferol—both inadequate and deficient—both of which are low.
Keywords: Calciferol (Vitamin-D), Levels of blood sugar, Poorly Controlled Type-2 Diabetes
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