Effect of Lead Toxicity and its Correlation with Different Variables of DNA Damage

  • Fahmida Khatoon Associate Professor, United Medical and Dental College, Karachi
  • Ayesha Pervez Assistant Professor, Amna Inayat Medical College, Sheikhupura
  • Fozan Ahmad Assistant Professor, Fatima Memorial College of Medicine and Dentistry Lahore
Keywords: Hemoglobin, Reactive Oxygen Species


Objective: To establish correlations of blood lead levels with DNA damage in population frequently exposed to lead in urban city.
Patients and Methods: This cross-sectional study was carried out in 60 traffic police wardens working in nine different administrative towns of Lahore. Cases were selected according to inclusion and exclusion criteria through stratified random sampling using proportional allocation. Total 30 healthy controls were taken from University of Health Sciences. Blood samples were drawn after informed consent. Blood lead concentration was determined by atomic absorption spectrometer and DNA damage by comet assay method. Data analysis was done by SPSS version 18. Correlation between lead level and DNA damage was studied.
Results: Police wardens working in open environment had significantly higher mean values of blood lead. Mean serum lead levels in study group exposed to lead were significantly elevated as compared with control group. Their blood lead levels were correlated with different variables of DNA damage.
Conclusion: As a result of industrial development, individuals exposed to lead due to their professional work, had significantly higher mean values of blood lead.

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