Effect of Aloevera Whole Leaf Extract in Combination with Rosiglitazone on Oxidative Stress and Lipid Profile Levels in Type-2 Diabetic Rats

  • Meena Gul Associate Professor, Department of Physiology, Gajju Khan Medical College, Swabi
  • Sadia Moazzam Professor, Department of Physiology, Fazaia Medical College Islamabad
  • Ifthikar Adil Assistant Professor, Department of Pharmacology, Gajuu Khan Medical College, Swabi
Keywords: Aloevera, Diabetes Mellitus type 2, Oxidative Stress, Rosiglitazone


Objective: To measure the synergistic effects of Aloevera and Rosiglitazone on plasma glucose, oxidative stress and lipid profile in Type-2 Diabetic Sprague-Dawley rats.
Subjects and Methods: A Randomized control trail was carried out in Physiology department of Army Medical College, Rawalpindi. Twenty healthy rats were made diabetic according to Srinivasan model. After confirmation of type 2 Diabetes, they were randomly segregated into two equal groups. Groups were named as diabetic control group and Diabetic treatment group. Control group was injected normal saline and treatment group was given 150 mg/kg body weight of Aloevera extract and 2.5mg/kg body weight of rosiglitazone. It was half of the effective doses which were calculated through pilot study.
Results: Plasma glucose, Malondialdehyde and lipid profile were significantly reduced (p<0.000) in diabetic treatment group as compared to diabetic control group.
Conclusion: A significant reduction in plasma glucose, oxidative stress and lipid profile was obtained in diabetic treatment group although half of the effective doses were used. It would also be help in reducing side effects associated with use of rosiglitazone.

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