Leptin to Adiponectin ratio as Atherogenic Index in Ischemic Heart Disease Patients

  • Muhammad Kashif Nisar Associate professor, Department of Biochemistry, Liaquat National Hospital & Medical College
  • Erum Afaq Assistant Professor, Department of Physiology, Liaquat National Hospital & Medical College
  • Humera Afaq Post graduate resident medical officer, Internal Medicine, Abbasi Shaheed Hospital, Karachi
  • Anila Jaleel Professor &HOD, Department of Biochemistry, FMH College of Medicine and Dentistry, Lahore
  • Adnan Zuberi Professor, Department of Chemical Pathology, Ziauddin University
Keywords: Adeponectin, LA ratio Leptin


Objective: To determine plasma adiponectin and leptin levels in subjects with and without ischemic heart disease (IHD) and to find the correlation between leptin, adiponectin to the number of coronary vessels disease-using angiography.
Patients and Methods: This is a cross-sectional study conducted Ziauddin University. 80 subjects were recruited who were undergoing angiography. Height, weight, Waist and hip circumference were measured. BMI and WHR were calculated accordingly. Venous blood was drawn to measure adiponectin and leptin using ELISA.
Results: Leptin to adiponectin ratio (LA ratio) was significantly increased in three and two vessel disease compared with single vessel and non-significant groups.
Conclusion: The study shows that adiponectin decreases and leptin increases in multivessel disease. LA ratio has been found to correlate well in two and more than two vessel disease.

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