Antimicrobial Sensitivity Pattern for Urine Isolates in Urinary Tract Infection

Kiran Tauseef Bukhari; Haseeb Tauseef Bukhari; Humaira Zafar; Mudassira Zahid

doi:10.35787/jimdc.v8i4.325

Kiran Tauseef Bukhari Associate Professor, Department of Pathology, Al Nafees Medical College & Hospital, Islamabad.
Haseeb Tauseef Bukhari PG Trainee FCPS Part-II, Surgical Unit-II, Holy Family Hospital, Rawalpindi
Humaira Zafar PG Trainee FCPS Part-II, Surgical Unit-II, Holy Family Hospital, Rawalpindi
Mudassira Zahid Assistant Professor, Department of Pathology, Al Nafees Medical College & Hospital, Islamabad

DOI: https://doi.org/10.35787/jimdc.v8i4.325

Keywords: Anti-microbial sensitivity, Carbapenems, Phosphonic acid derivatives, Polymyxins, Urinary tract infection, Urine isolates

Abstract

Background: The increased frequency and management of antibiotic resistance pattern in urinary tract infection (UTI) is a challenging task for the clinicians. Therefore, the current study was planned to identify the microbial etiology of UTI and the most suitable antibiotics used. The objective of the study was to assess the frequency of antimicrobial sensitivity pattern in patients with urinary tract infection.
Material and Methods: This cross-sectional study was carried out at Al Sayed Hospital, Kidney Centre, Rawalpindi over a period of seven months i.e. June 30, 2018 to January 30, 2019. A total of 152 patients were enrolled according to the inclusion and exclusion criteria of the study. Urine culture proceedings were done as per latest recommended guidelines of Clinical and Laboratory Standard Institute (CLSI) for UTI.
Results: Regarding overall sensitivity of antibiotics for the pathogens of urine culture, highest sensitivity was observed for carbapenems (83.5%), followed by polymyxin B (72.3%), phosphonic acid derivatives (65.8%), aminoglycoside group (65.7%), extended spectrum penicillin (63.1%), imidazolidinedione (59.9%) and tetracycline (59.9%) groups. The least sensitivity was observed for Oxazolidinone (linezolid) (14.5%), teicoplanin (13.8%), tigecycline (10.5%) and first-generation cephalosporins (1.3%).
Conclusions: Carbapenems showed maximum sensitivity for all urine isolates. The second and third options were polymyxin B and phosphonic acid derivatives, respectively.