Pattern of Dyslipidemias and their Association with Ischemic and Hemorrhagic Stroke
Objective: To find out the association between dyslipidemias and ischemic and hemorrhagic stroke.
Patients and Methods: This cross-sectional study was conducted in Medical Unit I, Jinnah Hospital Lahore (JHL) from 1st January 2015 to 30th Jun 2015. A total of 420 cases of stroke were included via Nonprobability consecutive sampling technique. The sample size was calculated with 95% confidence level, 2% margin of error. At the time of admission, every patient underwent CT scan in the radiology department of JHL, fasting blood samples were taken, on next day of admission. Every sample was processed for lipid profile in pathology department of Allama Iqbal Medical College, (AIMC) Lahore. Based on CT scan findings, patients were labelled as ischemic or hemorrhagic stroke. Demographic details, BMI, blood pressure and Diabetic status were also recorded.
Results: Out of 420 study participants, 47.6% (n=200) were male and 52.4% (n=220) were females, the mean age was 39.29 + 11.82 years, mean BMI was 39.29 + 11.82 kg/m2. History of hypertension (HTN) was most frequent risk factor seen in 82.6% (n=347) followed by Diabetes mellitus (DM) 49.8% (n=209) and smoking found in 32.1% (n=135) cases. Frequency of Hypercholesterolemia (>200 mg/dl) was observed in 26.2% (n=110) and Hypertriglyceridemia (>150 mg/dl) in 7.9% (n=33) patients. High LDL (>130 mg/dl) levels were observed in 5.7% (n=24), high VLDL (>35 mg/dl) in 6.9% (n=29) patients, while low HDL (<35 mg/dl) was noticed in 17.1% (n=72) patients. There was significant association between type of stroke & hypercholesterolemia as well as low HDL levels (p-value<0.05). While insignificant association was found between type of stroke & hypertriglyceridemia and high VLDL (p-value>0.05). Effect modifiers i.e.; age, BMI, gender, history of smoking, HTN and DM were not significantly associated with type of stroke (p-value >0.05).
Conclusion: Hypercholesterolemia & HDL levels are significantly associated with type of stroke, whereas serum hypertriglyceridemia, high LDL and high VLDL were not significantly associated with type of stroke.
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