Association between Gly460Trp Polymorphism of αAdducin Gene and Risk Factors in Hypertensive Pakistani Population

  • Hamid Ali Head of MLT Department, Islamabad Medical & Dental College, Islamabad
  • Qurat -Ul-Ain Zia .Senior Lecturer, Biochemistry Department, Islamabad Medical & Dental College, Islamabad
Keywords: rs4961, Alpha adducin gene, Body mass index,, Hypertension

Abstract

Objective: To determine possible association between αadducin gene G460W polymorphism and risk factors like age & BMI in hypertensive Pakistani population.
Material & Methods: Deoxyribonucleic acid (DNA) samples from 200 patients with essential hypertension and 200 normotensive healthy individuals from Pakistani population were genotyped for G460W polymorphism by Polymerase Chain Reaction and Restriction Fragment Length Polymorphism. Logistic regression analysis was used to find association between ADD1 gene G640W polymorphism and risk factors like age and BMI (Body mass index) in hypertensive Pakistani population.
Results: No significant association was found between G640W polymorphism and risk factors like age and obesity.
Conclusion: This study showed that there is no significant association between ADD1 gene G640W polymorphism and risk factors in our selected samples from Pakistani population.

Published
2017-01-09
Issue
Vol 5 No 4 (2016): October-December 2016
Section
Original Articles

Creative Commons License
This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.