Fetomaternal Outcomes in Pregnant Women with Intrahepatic Cholestasis of Pregnancy in Third Trimester

Abstract

Objective: To determine the fetal outcome in pregnant women with intrahepatic cholestasis in the third trimester.

Methodology: Patients aged 18 to 45, with a gestational age of at least 24 weeks and a diagnosis of intrahepatic cholestasis of pregnancy, were included. Exclusion criteria included having cholelithiasis or choledocholithiasis on ultrasonography, having a shrunken or echogenic liver on ultrasonography, having a platelet count of less than 100,000/microlitre at study enrollment, having a diagnosis of PIH or pre-eclampsia, or not knowing their LMP. Under the guidance of a specialist gynaecologist with at least three years of post-fellowship experience, the researcher herself evaluated each participant every two weeks and monitored them till birth.

Results: Preterm delivery in 38 (25.33%), NICU admission in 23 (15.33%), meconium-stained liquor in 13 (8.67%), cesarean delivery in 85 (56.67%), postpartum hemorrhage in 53 (35.33%), and perinatal death in 11 (7.33%) were the fetomaternal outcomes in this study among pregnant women with intrahepatic cholestasis of pregnancy in the third trimester.

Conclusion: IHCP is linked to negative outcomes for both the mother and the fetus (preterm, NICU admission, and perinatal death).

Keywords: Intrahepatic cholestasis, NICU, Outcome, Perinatal death, Preterm Outcome