Spectrum of Bone Lesions at Pakistan Institute of Medical Sciences
Objective: To study demographic details of bone lesions diagnosed at Pakistan Institute of Medical Sciences (PIMS), Islamabad Patients and Methods: A retrospective analysis of histopathology reports of 222 patients diagnosed to have various types of bone lesion, in the department of pathology at Pakistan Institute of Medical Sciences, Islamabad during a period of five years (July 2005- June 2010) was conducted. These biopsies were evaluated on hematoxylin and eosin (H&E) stained sections from paraffin embedded tissue blocks. Special stains performed whenever required. Results: Pyogenic osteomyelitis comprised 43.6% of all bone pathologies, followed by granulomatous most probably tuberculous osteomyelitis in 7.6%. Chronic osteomyelitis was more commonly observed in 20-30 years of age group and males were affected more as compared to females. The commonest age group for benign lesion was 11-20 years. Primary malignant tumors were noted in 4.9% cases and metastatic tumors were seen in 14.4%. The commonest age group for metastatic tumors was more than 50 years of age. Males were affected more as compared to females in overall bone lesions. Femur was the commonest site in primary bone lesions. Jaw bones and scalp were more commonly involved metastatic tumors. Conclusions: Metastatic tumors were more common than primary malignancies. Scalp and mandible involvement was seen in metastatic tumors and bones of lower limbs were more commonly involved in primary bone lesions. Males were more commonly affected than females in this study.
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