Effect of Beclomethasone Dipropionate Versus Mast Cell Stabilizer on Mucociliary Clearance in Patients of Allergic Rhinitis

  • Muhammad Ramzan Ex House officer Nishtar Hospital Multan
  • Nasir Iqbal Ex House officer, Medical officer BHU Wandher Multan
  • Arslan Karim Ex House officer, Medical officer BHU Qadir Pur Multan
Keywords: Allergy, Beclomethasone Dipropionate, Mucociliary clearance, Nedocromil sodium, Rhinitis, Saccharine dye test


Objective: The study was conducted to compare the effect of Beclomethasone dipropionate with mast cell stabilizer on mucociliary clearance in patients of allergic rhinitis.
Patients and Methods: A randomized trial was carried out in ENT department of Nishtar Hospital Multan from December 2016 to February 2017. Patients of allergic rhinitis from both genders were included in the study after written consent. Mucociliary transport velocity was measured by saccharine dye test. The collected data was processed and analyzed by SPSS software 23 version and presented in tabulation form. Qualitative variables were analyzed in percentage and frequency form. The main outcome variable, mucociliary transport velocity, age and weight of patients were presented as mean and stranded deviation. Students’ test was applied to calculate p value. P value <0.05 was taken as significant.
Results: A total number of 140 patients were included in the study and were divided in two main groups. There were 70 volunteers in each group.  One group was provided Beclomethasone and other group was given mast cell stabilizer for one week.  After careful analysis and calculation, it was observed that the mean of mucociliary transport velocity after one week of Beclomethasone dipropionate treatment was 7.33±1.27 mm/minute with p value 0.558 and mean of velocity after mast cell stabilizer (Nedocromil sodium) was 7.82±1.2 mm/minute with p-values 0.304.
Conclusion: No statistical significance was found with both treatment regimens.

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