Peripheral Blood Parameters in Patients of NonHodgkin’s Lymphomas Showing Bone Marrow Infiltration
Background: Non-Hodgkin’s lymphomas are frequently characterized by bone marrow infiltration. Peripheral blood counts and examination of blood smears are essentially performed along with bone marrow biopsy in the pretreatment investigations. Variations in peripheral blood counts are believed to have prognostic implication. Objectives: To look into various types of cytopenias and presence of atypical lymphoid cells in the peripheral blood of patients of non-Hodgkin’s lymphoma showing bone marrow infiltration. Materials and Methods: This descriptive study was performed in the department of Pathology, Pakistan Institute of Medical Sciences from January 2,004 to December, 2,004. A total of 50 consecutive patients of non-Hodgkin’s lymphoma belonging to all age groups and both sexes, and showing bone marrow infiltration on aspiration and trephine biopsies were included. Peripheral blood counts were performed on an automated haematology analyzer. Blood smears stained by Wright stained were scanned for atypical lymphoid cells. In the differential leucocyte count, 500 cells were counted. Results: Cytopenias of all types were frequently observed. Anaemia was the commonest finding (94%), followed by thrombocytopenia (62%) and neutropenia (34%). Bicytopenia was noted in 38% and thrombocytopenia in 30% of cases. Atypical cells were observed in the blood smears of 64% of patients. Conclusions: Anaemia alone or as a part of bicytopenia or pancytopenia is common finding in patients of non-Hodgkin’s lymphoma showing bone marrow infiltration. A detailed examination of stained blood smears shows atypical lymphoid cells in 64% of patients. Key
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