Comparing the Pretreatment with Lignocaine 40 mg and Fentanyl 100 ug as an Adjuvant for Preclusion of Pain Associated with Intravenous Propofol Injection

  • Syed Adnan Alam Assistant Professor , Anesthesia Department , Bannu Medical College
  • Rashid Ullah Khan Assistant Anesthetist , Pakistan Institute of Medical Sciences , Islamabad
  • Muhammad Bilal Anesthesiologist, Anesthesia Department ,Polyclinic Hospital , Islamabad
  • Khurram Liaqat Consultant Anaesthetist, Department of Anaesthesia and Surgical ICU ,Polyclinic Hospital , Islamabad.
  • Afia Rahna Assistant Consultant , Department of Anesthesia , Maroof International Hospital, Islamabad
  • Javed Iqbal Medical Officer, Anesthesia , Polyclinic Hospital , Islamabad



Background: Propofol (2,6-di-isopropylphenol) is one of the most favored drugs used for induction of anesthesia. Pain on injection is a common problem. Various methods have been tried to alleviate this pain but with conflicting results.

Objective: To compare effectiveness of lignocaine versus fentanyl in patients receiving propofol for general anesthesia in population of Pakistan who come to PIMS hospital in Islamabad.

Materials and Methods: 120 participants of either sex, between 18 and 40 years of age, belonging to ASA physical status I and II, undergoing elective surgery under general anesthesia, were randomized into two equal groups of 60 participants. They received, intravenously, either lignocaine 2 ml (20 mg/ml )or fentanyl 2 ml (50 mcg/mL) as a pretreatment before propofol injection.

Results: The efficacy of lignocaine as a pretreatment drug injection was higher (96.7%) compared to fentanyl (85.0%). In the lignocaine group, 2.3% of the participants experienced pain as compared with 15% in the fentanyl group (P<0.05).

Conclusion: Compared with fentanyl, lignocaine pretreatment was more effective in preventing pain on propofol injection.

KEY WORDS: Comparison, Fentanyl, LIgnocaine, Propofol, Pain.

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