Validity and Accuracy of FNAC in the Diagnosis of Pleomorphic Adenoma of Salivary Gland: A Clinico-pathological Study
Objective: The first objective of the study was to analyze frequency of pleomorphic adenoma with reference to site involvement (i.e., parotid, submandibular, sublingual and minor salivary glands).Second objective was to determine sensitivity and specificity of Fine needle aspiration cytology (FNAC) for diagnosis of pleomorphic adenoma considering histopathology report as gold standard
Patients and Methods: This cross sectional study of pleomorphic adenoma of salivary glands was conducted at the Department of otolaryngology, Capital Hospital, Islamabad over a period of 5 years from May 1st, 2007 to April 30th 2012. This study included 50 diagnosed cases of pleomorphic adenoma, of either gender above 30 years of age. Cases who had already received treatment and those in which histopathology reports were not available were excluded from the study. Clinical data included parameters like age and sex distribution, site/ gland involvement, FNAC and histopathology reports were collected. Data was tabulated and analyzed using Microsoft Excel Worksheet. Qualitative data was presented by frequency and percentage and quantitative was calculated as mean + SD. Variables specially studied included frequency of site involvement, and sensitivity and specificity of FNAC.
Results: This study included a total of 50 patients, out of which 20 (40%) were males and 30 (60%) were females with a male female ratio of 1:1.5. Age range was 30 to 50 years with mean age of 37.92 + 6.26 years. Sites involved were, parotid in 24 (48%) patients, submandibular in 12 (24%) patients, and minor salivary glands in 14 patients (28%). FNAC done for diagnosis, had a sensitivity and specificity of 87.5% and 40% respectively with an accuracy rate of 78%.
Conclusion: FNAC is highly sensitive for the diagnosis of pleomorphic adenoma and should be performed in all such cases without undermining the importance of imaging studies.
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